Insulin independence after living-donor distal pancreatectomy and islet allotransplantation

Lancet. 2005 May 7-13;365(9471):1642-4. doi: 10.1016/s0140-6736(05)66383-0.


Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a successful transplantation of living-donor islets for unstable diabetes. The recipient was a 27-year-old woman who had had brittle, insulin-dependent diabetes mellitus for 12 years. The donor, who was a healthy 56-year-old woman and mother of the recipient, underwent a distal pancreatectomy. After isolation, 408 114 islet equivalents were transplanted immediately. The transplants functioned immediately and the recipient became insulin-independent 22 days after the operation. The donor had no complications and both women showed healthy glucose tolerance. Transplantation of living-donor islets from the distal pancreas can be sufficient to reverse brittle diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / surgery*
  • Female
  • Humans
  • Islets of Langerhans Transplantation*
  • Living Donors*
  • Middle Aged
  • Pancreatectomy / methods*
  • Pancreatitis / complications
  • Tissue and Organ Harvesting / methods*