Improved protection by recombinant BCG

Microbes Infect. 2005 May;7(5-6):939-46. doi: 10.1016/j.micinf.2005.03.012. Epub 2005 Apr 15.


Mycobacterium bovis bacille Calmette Guérin (BCG) is one of the most widely used live vaccines. Technologic advancement in genome manipulation enables the construction of recombinant BCG (rBCG) strains, which can be employed as highly immunogenic vaccines against tuberculosis with improved safety profile.

MeSH terms

  • BCG Vaccine* / administration & dosage
  • BCG Vaccine* / adverse effects
  • Humans
  • Tuberculosis / prevention & control*
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / adverse effects


  • BCG Vaccine
  • Vaccines, Synthetic