Prime-boost immunisation strategies for tuberculosis

Microbes Infect. 2005 May;7(5-6):962-7. doi: 10.1016/j.micinf.2005.03.009. Epub 2005 Apr 15.


Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained.

Publication types

  • Review

MeSH terms

  • Humans
  • Immunization Schedule*
  • Immunization, Secondary*
  • Tuberculosis Vaccines / administration & dosage*


  • Tuberculosis Vaccines