Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults

Atherosclerosis. 2005 Dec;183(2):342-8. doi: 10.1016/j.atherosclerosis.2005.03.017.


Aims: The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking.

Methods and results: Our study is based on a subset of participants in the Atherosclerosis Risk in Communities (ARIC) Study, who received a complete periodontal examination during visit 4 (1996-1998). The outcome was mean carotid IMT>/=1mm assessed by B-mode ultrasound. The exposures were serum IgG antibody levels against 17 periodontal organisms using a whole bacterial checkerboard immunoblotting technique. Evaluation of all 17 antibodies indicated that antibody to Campylobacter rectus resulted in the best-fitting model (OR=2.3, 95% CI=1.83-2.84) and individuals with both high C. rectus and Peptostreptococcus micros titers had almost twice the prevalence of IMT>/=1mm than those with only a high C. rectus antibody (8.3% versus 16.3%). Stratification by smoking indicated that all microbial models significant for smokers were also significant for never smokers except for Porphyromonas gingivalis (p=0.08).

Conclusions: This is the first study to report a relationship between IgG antibody reactive to oral organisms and subclinical atherosclerosis with significant relationships evident in both ever and never smokers.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Anti-Idiotypic / immunology*
  • Atherosclerosis / epidemiology
  • Atherosclerosis / etiology
  • Bacteria / immunology*
  • Bacteria / isolation & purification
  • Bacterial Infections / complications
  • Bacterial Infections / immunology
  • Bacterial Infections / microbiology
  • Carotid Arteries / diagnostic imaging*
  • Carotid Artery Diseases / epidemiology
  • Carotid Artery Diseases / etiology
  • Female
  • Humans
  • Immunoglobulin G / immunology*
  • Incidence
  • Male
  • Middle Aged
  • Mouth / microbiology*
  • Periodontitis / complications
  • Periodontitis / immunology*
  • Periodontitis / microbiology
  • Prospective Studies
  • Residence Characteristics
  • Risk Factors
  • Tunica Intima / diagnostic imaging*
  • Ultrasonography
  • United States / epidemiology


  • Antibodies, Anti-Idiotypic
  • Immunoglobulin G