Subcellular localization and trafficking of polycystins

Pflugers Arch. 2005 Oct;451(1):286-93. doi: 10.1007/s00424-005-1417-3. Epub 2005 May 14.


Polycystin-2 is a member of the transient receptor potential (TRP) family of ion channels that is mutated in autosomal dominant polycystic kidney disease. Although its function as a non-selective cation channel has been demonstrated in several model systems, the precise subcellular localization of polycystin-2 (TRPP2) in tubular epithelial cells has remained controversial. Recent evidence suggests that the subcellular localization of TRPP2 is regulated by multiple protein interactions. This review will summarize our current knowledge about polycystin trafficking and highlight the experimental data that supports a compartment-specific function of 'cystogenic' proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Cilia / chemistry
  • Humans
  • Polycystic Kidney, Autosomal Dominant / physiopathology*
  • Protein Transport
  • TRPP Cation Channels / metabolism*


  • TRPP Cation Channels
  • polycystic kidney disease 1 protein
  • polycystic kidney disease 2 protein