Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Mar;58(3):210-3.
doi: 10.1038/ja.2005.26.

Deoxyverrucosidin, a Novel GRP78/BiP Down-Regulator, Produced by Penicillium Sp

Affiliations

Deoxyverrucosidin, a Novel GRP78/BiP Down-Regulator, Produced by Penicillium Sp

Soo-Jin Choo et al. J Antibiot (Tokyo). .

Abstract

Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC50 of 30 nM.

Similar articles

See all similar articles

Cited by 7 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback