A putative nuclear function for mammalian Staufen

Trends Biochem Sci. 2005 May;30(5):228-31. doi: 10.1016/j.tibs.2005.03.005.


In addition to its role in rRNA processing and ribosome assembly, the nucleolus plays a part in the assembly of non-ribosomal ribonucleoprotein particles (RNPs) that are destined for cytoplasmic RNA delivery. Recent evidence indicates that mammalian Staufen2, a brain-specific RNA-binding protein involved in RNA localization, can--at least transiently--enter the nucleolus. Therefore, the assembly of Staufen2 into transport-competent RNPs might occur in the nucleus before their export into the cytoplasm. This could provide new insights into the mechanisms of subcellular RNA localization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus
  • Adenosine Deaminase / metabolism
  • Animals
  • Cell Nucleolus / metabolism*
  • Models, Biological
  • Protein Isoforms / metabolism
  • RNA / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Ribonucleoproteins / biosynthesis


  • Protein Isoforms
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • staufen protein, mammalian
  • RNA
  • ADARB1 protein, human
  • Adenosine Deaminase