Review
doi: 10.1016/j.tibs.2005.03.011.
Mediator and the mechanism of transcriptional activation
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- PMID: 15896740
- DOI: 10.1016/j.tibs.2005.03.011
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Review
Mediator and the mechanism of transcriptional activation
Trends Biochem Sci.
2005 May.
Abstract
Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system - it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer-->activator-->Mediator-->pol II-->promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.
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