Catalytic Enantioselective Thioester Aldol Reactions That Are Compatible With Protic Functional Groups

J Am Chem Soc. 2005 May 25;127(20):7284-5. doi: 10.1021/ja051759j.


This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.