Evaluation of a rapid bedside test for the quantitative determination of C-reactive protein

Clin Chem Lab Med. 2005;43(4):438-40. doi: 10.1515/CCLM.2005.077.


Regardless of its origin, any condition associated with inflammation is accompanied by an increase in serum C-reactive protein levels. This study compared the results of a rapid test for the bedside assay of C-reactive protein (QuikRead CRP, Orion Corporation, Orion Diagnostica, Espoo, Finland) with those of a standard laboratory assay in samples taken from 231 children aged less than 14 years (126 males; median age 4.7 years) attending the Emergency Department of Milan University's Institute of Pediatrics because of acute respiratory infection. The two methods showed similar median C-reactive protein levels (standard laboratory assay: 34.7 mg/L, range 4-199 mg/L; QuikRead CRP: 33.3 mg/L, range <8-196 mg/L; p = 0.779) and a similar distribution of children with C-reactive protein levels of <20 mg/L, 20-70 mg/L and >70 mg/L. This study shows for the first time that the rapid QuikRead CRP test can be performed at the bedside or in an outpatient clinic and, in less than 5 min, gives the same quantitative results as those obtained using a more complex routine laboratory method.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • C-Reactive Protein / analysis*
  • C-Reactive Protein / immunology
  • Child
  • Child, Preschool
  • Emergency Service, Hospital
  • Female
  • Hospitals, University
  • Humans
  • Immunoassay / methods*
  • Infant
  • Infant, Newborn
  • Italy
  • Male
  • Point-of-Care Systems / standards*
  • Reproducibility of Results
  • Time Factors


  • C-Reactive Protein