The metastasis associated protein S100A4: role in tumour progression and metastasis

Br J Cancer. 2005 Jun 6;92(11):1955-8. doi: 10.1038/sj.bjc.6602613.


The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Movement
  • Cell Transformation, Neoplastic*
  • Disease Progression
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasm Invasiveness*
  • Neoplasm Metastasis / genetics*
  • Neoplasm Metastasis / physiopathology*
  • Neoplasms / genetics*
  • Neoplasms / pathology*
  • Neovascularization, Pathologic
  • Phenotype
  • Prognosis
  • S100 Calcium-Binding Protein A4
  • S100 Proteins / genetics*
  • S100 Proteins / physiology*


  • S100 Calcium-Binding Protein A4
  • S100 Proteins
  • S100A4 protein, human