Abstract
We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Cyclization
-
HIV Envelope Protein gp41 / chemistry*
-
Molecular Structure
-
Oligopeptides / chemical synthesis*
-
Oligopeptides / chemistry
-
Sulfides / chemical synthesis*
Substances
-
HIV Envelope Protein gp41
-
Oligopeptides
-
Sulfides