Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

Chem Commun (Camb). 2005 May 28:(20):2552-4. doi: 10.1039/b419015g. Epub 2005 Mar 11.

Abstract

We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cyclization
  • HIV Envelope Protein gp41 / chemistry*
  • Molecular Structure
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Sulfides / chemical synthesis*

Substances

  • HIV Envelope Protein gp41
  • Oligopeptides
  • Sulfides