Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts

Curr Opin Cell Biol. 2005 Jun;17(3):274-80. doi: 10.1016/


Metazoan replication-dependent histone mRNAs are the only eukaryotic mRNAs that lack polyA tails. The genes for the five histone proteins have remained physically linked during evolution. Expression of histone mRNAs and histone proteins requires a unique set of factors, and may be coordinated by association of the histone genes with Cajal bodies. Recently several novel factors, including components of the U7 snRNP, as well as proteins involved in regulation of histone gene expression, have been described.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • Base Sequence
  • Cell Nucleus / metabolism
  • Coiled Bodies / metabolism
  • Gene Expression Regulation
  • Histones / genetics*
  • RNA Polymerase II / metabolism*
  • RNA Processing, Post-Transcriptional
  • RNA Transport / physiology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Ribonucleoprotein, U7 Small Nuclear / genetics
  • Ribonucleoprotein, U7 Small Nuclear / metabolism
  • Transcription, Genetic*
  • mRNA Cleavage and Polyadenylation Factors / metabolism


  • Histones
  • RNA, Messenger
  • Ribonucleoprotein, U7 Small Nuclear
  • mRNA Cleavage and Polyadenylation Factors
  • RNA Polymerase II