Acute fatty liver of pregnancy in 3 tertiary care centers

Am J Obstet Gynecol. 2005 May;192(5):1416-9. doi: 10.1016/j.ajog.2004.12.035.


Objective: The purpose of this study was to determine the demographics, clinical presentation, and maternal and neonatal outcomes in patients who were diagnosed with acute fatty liver of pregnancy over a 10-year period.

Study design: This was a multicenter retrospective study of women with the diagnosis of acute fatty liver of pregnancy. Records were reviewed for symptoms, laboratory findings, clinical course, and maternal and perinatal outcomes.

Results: Sixteen cases of acute fatty liver of pregnancy were identified. Three of the 16 cases had multiple gestations (18%). Eleven of the 16 cases were diagnosed in the antepartum period, and 5 cases were diagnosed within 4 days after delivery. Nausea and vomiting were the most common symptoms (75%). There were 2 maternal deaths (12.5%) and 3 fetal deaths (15%).

Conclusion: We recommend that patients with persistent nausea, vomiting, or epigastric pain in the third trimester receive evaluation of liver enzymes, renal function, and a complete blood count to rule out the diagnosis of acute fatty liver of pregnancy.

Publication types

  • Multicenter Study

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Fatty Liver* / complications
  • Fatty Liver* / diagnosis
  • Fatty Liver* / epidemiology
  • Female
  • Fetal Mortality
  • Gestational Age
  • Humans
  • Incidence
  • Postpartum Period
  • Pregnancy
  • Pregnancy Complications* / diagnosis
  • Pregnancy Complications* / epidemiology
  • Pregnancy Complications* / mortality
  • Pregnancy Outcome
  • Pregnancy, Multiple
  • Retrospective Studies