Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: a phantom study

Eur J Nucl Med Mol Imaging. 2005 Sep;32(9):1100-7. doi: 10.1007/s00259-005-1810-3. Epub 2005 May 18.


Purpose: (123)I presents imaging problems owing to high-energy photon emission. We investigated the influence of collimators on (123)I-MIBG heart/mediastinum ratios (H/M ratios). Secondly, we assessed the influence on H/M ratios of different activity concentrations, simulating clinical conditions. Thirdly, the value of scatter correction was assessed.

Methods: The AGATE cardiac phantom was filled with (123)I in three sequential conditions: A, heart and mediastinal activity; B, adding lung activity; and C, adding liver activity (protocol I). In protocol II, myocardium and liver were filled with different activities ranging from low to high. For each condition, static anterior planar and single-photon emission computed tomography studies were acquired on a Siemens (SI) and a General Electric Millennium VG (GE) system, using low-energy high-resolution and medium-energy (ME) collimators for protocol I and only ME collimators for protocol II . For the SI camera, a triple energy window (TEW) scatter correction was applied.

Results: Planar H/M ratios were influenced by scatter and septal penetration from increasing amounts of liver activity. These effects were less pronounced for ME collimators. Although the TEW scatter correction increased ratios overall, TEW correction did not improve the relative differences between the ratios. TEW correction therefore does not add any benefit to obtain an accurate reflection of myocardial activity concentrations.

Conclusion: For straightforward implementation of semi-quantitative (123)I-MIBG myocardial studies, we recommend the use of ME collimators without scatter correction.

Publication types

  • Comparative Study

MeSH terms

  • 3-Iodobenzylguanidine / pharmacokinetics*
  • Equipment Failure Analysis
  • Heart / diagnostic imaging*
  • Image Enhancement / instrumentation*
  • Mediastinum / diagnostic imaging*
  • Mediastinum / physiology
  • Myocardium / metabolism*
  • Organ Specificity
  • Phantoms, Imaging
  • Radionuclide Imaging / instrumentation*
  • Radionuclide Imaging / methods
  • Radiopharmaceuticals / pharmacokinetics
  • Reproducibility of Results
  • Scattering, Radiation
  • Sensitivity and Specificity
  • Tissue Distribution


  • Radiopharmaceuticals
  • 3-Iodobenzylguanidine