Effect of low-dose, short-duration creatine supplementation on anaerobic exercise performance

J Strength Cond Res. 2005 May;19(2):260-4. doi: 10.1519/15484.1.


To examine the efficacy of a low-dose, short-duration creatine monohydrate supplement, 40 physically active men were randomly assigned to either a placebo or creatine supplementation group (6 g of creatine monohydrate per day). Testing occurred before and at the end of 6 days of supplementation. During each testing session, subjects performed three 15-second Wingate anaerobic power tests. No significant (p > 0.05) group or time differences were observed in body mass, peak power, mean power, or total work. In addition, no significant (p > 0.05) differences were observed in peak power, mean power, or total work. However, the change in the rate of fatigue of total work was significantly (p < 0.05) lower in the creatine supplementation group than in the placebo group, indicating a reduced fatigue rate in subjects supplementing with creatine compared with the placebo. Although the results of this study demonstrated reduced fatigue rates in patients during high-intensity sprint intervals, further research is necessary in examining the efficacy of low-dose, short-term creatine supplementation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anaerobic Threshold / drug effects*
  • Anaerobic Threshold / physiology
  • Area Under Curve
  • Creatine / administration & dosage*
  • Dietary Supplements*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Exercise / physiology*
  • Humans
  • Male
  • Muscle Fatigue / drug effects
  • Muscle Fatigue / physiology
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / physiology
  • Running / physiology
  • Task Performance and Analysis*
  • Treatment Outcome


  • Creatine