Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation

J Strength Cond Res. 2005 May;19(2):358-63. doi: 10.1519/R-15844.1.


Cordyceps sinensis (Cs) and Rhodiola rosea (Rr) are herbs used in traditional Chinese medicine to treat a multitude of ailments as well as to enhance performance. The purpose of this research was to examine the effects of a formula containing Cs and Rr (Cs-Rr) on circulatory dynamics, specifically muscle tissue oxygen saturation (Sto(2)), in male subjects during maximal exercise. This study followed a double blind, randomized, placebo-treatment, pre-post test design. Capsules were administered to 8 subjects who were randomly assigned to 1 of 2 groups. The treatment group received Cs-Rr, and the control group received a placebo. All subjects performed 2 exercise stress tests to volitional fatigue on a cycle load ergometer. There were no significant (p </= 0.05) differences in Sto(2) slope, Sto(2) threshold (Sto(2T)), Vo(2)max, ventilatory threshold (V(T)), or time to exhaustion (T(E)) between or within the treatment or control group. In conclusion, Cs-Rr did not significantly enhance Sto(2).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Bicycling / physiology*
  • Cordyceps*
  • Dietary Supplements*
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / blood supply
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism*
  • Oxygen Consumption / drug effects*
  • Oxygen Consumption / physiology
  • Phytotherapy / methods*
  • Plant Preparations / administration & dosage
  • Regional Blood Flow / drug effects
  • Regional Blood Flow / physiology
  • Rhodiola*
  • Treatment Outcome


  • Plant Preparations