Nonequilibrium model for estimating parameters of deleterious mutations

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Mar;71(3 Pt 1):031907. doi: 10.1103/PhysRevE.71.031907. Epub 2005 Mar 18.


Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological / genetics
  • Animals
  • Biological Evolution*
  • Computer Simulation
  • Genetic Variation / genetics*
  • Genetics, Population / methods*
  • Humans
  • Models, Genetic*
  • Models, Statistical
  • Mutation / genetics*
  • Population Dynamics*
  • Selection, Genetic*
  • Stochastic Processes
  • Survival Analysis