A cost of long-term memory in Drosophila

Science. 2005 May 20;308(5725):1148. doi: 10.1126/science.1111331.


Two distinct forms of consolidated associative memory are known in Drosophila: long-term memory and so-called anesthesia-resistant memory. Long-term memory is more stable, but unlike anesthesia-resistant memory, its formation requires protein synthesis. We show that flies induced to form long-term memory become more susceptible to extreme stress (such as desiccation). In contrast, induction of anesthesia-resistant memory had no detectable effect on desiccation resistance. This finding may help to explain why evolution has maintained anesthesia-resistant memory as another form of consolidated memory, distinct from long-term memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Evolution
  • Conditioning, Psychological
  • Drosophila Proteins / biosynthesis
  • Drosophila melanogaster / physiology*
  • Female
  • Male
  • Memory / physiology*
  • Odorants
  • Starvation
  • Water Deprivation


  • Drosophila Proteins