Inflammatory bowel disease in patients with celiac disease

Inflamm Bowel Dis. 2005 Jun;11(6):528-32. doi: 10.1097/01.mib.0000161308.65951.db.


Background: Several case reports and series report an association between celiac disease and inflammatory bowel disease (IBD); however, there is no current data assessing this association. We therefore studied the occurrence of these conditions in a cohort of patients with celiac disease seen at a referral center.

Methods: A database of patients with celiac disease seen between 1981 and 2002 was analyzed. Only biopsy-proven adults were included. Patients who had endoscopic and pathologic evidence of IBD were identified, and their pathology was reviewed. Age- and sex-adjusted prevalence rate ratios were determined by comparing results with population-based prevalence data.

Results: Among 455 patients with celiac disease, IBD was identified in 10 (5 had ulcerative colitis and 5 had Crohn's disease). This represented an age- and sex-adjusted prevalence rate ratio for ulcerative colitis of 3.56 (95% confidence interval, 1.48-8.56) and for Crohn's disease of 8.49 (95% confidence interval, 3.53-20.42).

Conclusion: Within our cohort of patients with celiac disease, IBD was significantly more common than in the general population.

MeSH terms

  • Adult
  • Age Factors
  • Celiac Disease / complications*
  • Cohort Studies
  • Female
  • Humans
  • Inflammatory Bowel Diseases / epidemiology*
  • Inflammatory Bowel Diseases / etiology*
  • Male
  • Middle Aged
  • Prevalence
  • Retrospective Studies
  • Sex Factors