Childhood solid tumours: a developmental disorder

Nat Rev Cancer. 2005 Jun;5(6):481-8. doi: 10.1038/nrc1633.


Several lines of evidence demonstrate that the biology, genetics and environment of childhood solid tumours (CSTs) sets them apart from adult solid tumours. The nature of the progenitor cells from which these tumours arise, and their immature tissue environment, allows CSTs to develop with fewer defects in cell regulatory processes than adult cancers. These differences could explain why CSTs are more susceptible to therapeutic intervention than adult tumours. How does the aetiology of these cancers differ from those occurring in adults and how might this affect the development of more effective therapies?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic*
  • Child
  • Child Development*
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / physiopathology*
  • Organogenesis