The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

Antimicrob Agents Chemother. 1992 Jan;36(1):202-5. doi: 10.1128/AAC.36.1.202.

Abstract

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Cytosine / analogs & derivatives*
  • Cytosine / pharmacology
  • HIV-1 / drug effects*
  • HIV-2 / drug effects*
  • Humans
  • Lamivudine
  • Stereoisomerism
  • Structure-Activity Relationship
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • Lamivudine
  • Cytosine