Abstract
Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.
MeSH terms
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Antiviral Agents / pharmacology*
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Cells, Cultured
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Chromatography, High Pressure Liquid
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Cytosine / analogs & derivatives*
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Cytosine / pharmacology
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HIV-1 / drug effects*
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HIV-2 / drug effects*
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Humans
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Lamivudine
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Stereoisomerism
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Structure-Activity Relationship
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Lamivudine
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Cytosine