A Screen of the Complete Protein Kinase Gene Family Identifies Diverse Patterns of Somatic Mutations in Human Breast Cancer

Nat Genet. 2005 Jun;37(6):590-2. doi: 10.1038/ng1571. Epub 2005 May 22.

Abstract

We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

MeSH terms

  • Aged
  • Breast Neoplasms / genetics*
  • Carcinoma, Ductal, Breast / genetics*
  • DNA Mutational Analysis
  • Female
  • Humans
  • Multigene Family
  • Mutation*
  • Protein Kinases / genetics*

Substances

  • Protein Kinases