Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension

Nat Struct Mol Biol. 2005 Jun;12(6):554-5. doi: 10.1038/nsmb939. Epub 2005 May 22.


The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Binding Sites
  • Cell Line
  • Crystallography, X-Ray
  • Humans
  • Hypertension / genetics*
  • Ligands
  • Mutagenesis
  • Mutagenesis, Site-Directed
  • Receptors, Mineralocorticoid / chemistry*
  • Receptors, Mineralocorticoid / genetics*
  • Recombinant Proteins / chemistry


  • Ligands
  • Receptors, Mineralocorticoid
  • Recombinant Proteins

Associated data

  • PDB/1Y9R
  • PDB/1YA3