Successful treatment with miltefosine of disseminated cutaneous leishmaniasis in a severely immunocompromised patient infected with HIV-1

Clin Infect Dis. 2005 Jun 15;40(12):e120-4. doi: 10.1086/430444. Epub 2005 Apr 27.


We describe here a case of disseminated cutaneous leishmaniasis due to Leishmania major in a severely immunocompromised patient from Burkino Faso, Africa, who is infected with human immunodeficiency virus-1. The skin lesions failed to respond to full treatment courses of amphotericin B, sodium stibogluconate, and liposomal amphotericin B but were successfully treated with miltefosine, an alkylphosphocholine analogue.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiprotozoal Agents / therapeutic use*
  • HIV Infections / complications*
  • Humans
  • Immunocompromised Host*
  • Leishmaniasis, Diffuse Cutaneous / drug therapy*
  • Leishmaniasis, Diffuse Cutaneous / etiology*
  • Male
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / therapeutic use
  • Skin / pathology


  • Antiprotozoal Agents
  • Phosphorylcholine
  • miltefosine