Antigen receptors on B lymphocytes

Annu Rev Immunol. 1992;10:97-121. doi: 10.1146/annurev.iy.10.040192.000525.

Abstract

Recent studies on the structure of the B cell antigen receptor demonstrate that the membrane-bound and antigen-binding immunoglobulin molecules are noncovalently associated with a heterodimer of two novel transmembrane proteins. The B cell antigen receptor is thus a multicomponent receptor complex whose structural features are similar to those of the T cell antigen receptor complex. Cross-linking of the B cell antigen receptor results in rapid tyrosine phosphorylation of substrate proteins. This suggests that the B cell receptor belongs to a subgroup of the tyrosine kinase receptor family with a noncovalently associated src-like tyrosine kinase.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / immunology
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Immunoglobulin D / genetics
  • Immunoglobulin M / chemistry
  • Immunoglobulin M / genetics
  • Molecular Sequence Data
  • Receptors, Antigen, B-Cell* / chemistry
  • Receptors, Antigen, B-Cell* / genetics

Substances

  • Immunoglobulin D
  • Immunoglobulin M
  • Receptors, Antigen, B-Cell