Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors

Peptides. 2005 Jun;26(6):1001-8. doi: 10.1016/j.peptides.2004.08.033. Epub 2005 Apr 15.


Natriuretic peptides are a family of hormones/paracrine factors that regulate blood pressure, cardiovascular homeostasis and bone growth. The mammalian family consists of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). A family of three cell surface receptors mediates their physiologic effects. Two are receptor guanylyl cyclases known as NPR-A/GC-A and NPR-B/GC-B. Peptide binding to these enzymes stimulates the synthesis of the intracellular second messenger, cGMP, whereas a third receptor, NPR-C, lacks enzymatic activity and functions primarily as a clearance receptor. Here, we provide a brief review of how various desensitizing agents and/or conditions inhibit NPR-A and NPR-B by decreasing their phosphorylation state.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Amino Acid Sequence
  • Animals
  • Calcium / metabolism
  • Cell Membrane / metabolism
  • Cyclic GMP / metabolism
  • Guanylate Cyclase / chemistry*
  • Guanylate Cyclase / metabolism
  • Humans
  • Molecular Sequence Data
  • Peptides / chemistry
  • Phosphorylation
  • Protein Binding
  • Receptors, Atrial Natriuretic Factor / chemistry*
  • Receptors, Atrial Natriuretic Factor / metabolism
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Vasodilation


  • Peptides
  • Adenosine Triphosphate
  • Guanylate Cyclase
  • Receptors, Atrial Natriuretic Factor
  • atrial natriuretic factor receptor B
  • Cyclic GMP
  • Calcium