Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2891-3. doi: 10.1016/j.bmcl.2005.03.111.


A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERalpha and ERbeta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Humans
  • Indoles / pharmacology*
  • Mice
  • Selective Estrogen Receptor Modulators / chemistry
  • Selective Estrogen Receptor Modulators / pharmacology*


  • Indoles
  • Selective Estrogen Receptor Modulators