Analyses comparing the antimicrobial activity and safety of current antiseptic agents: a review

J Infus Nurs. May-Jun 2005;28(3):194-207. doi: 10.1097/00129804-200505000-00008.

Abstract

This article reviews the results and conclusions from four pivotal and two comparative clinical trials. The six randomized, controlled, single-blinded, parallel-group clinical trials were conducted to determine which antiseptic is best for use as a patient preoperative skin preparation. The objective of these studies was to compare the immediate, persistent (residual), and cumulative antimicrobial efficacy and safety of 2% chlorhexidine gluconate (CHG) combined with 70% isopropyl alcohol (IPA) (ChloraPrep); another combination CHG and IPA antiseptic (CHG+IPA) and 2% aqueous CHG alone; 4% CHG (Hibiclens) alone; 70% isopropyl alcohol (IPA) alone; and an iodine-containing solution, 10% povidone-iodine (Betadine) alone as preoperative skin topical antiseptics for potential prevention of nosocomial infections.

MeSH terms

  • 2-Propanol / therapeutic use
  • Administration, Cutaneous
  • Anti-Infective Agents, Local / adverse effects
  • Anti-Infective Agents, Local / therapeutic use*
  • Antisepsis / methods*
  • Chlorhexidine / analogs & derivatives*
  • Chlorhexidine / therapeutic use
  • Clinical Trials as Topic* / standards
  • Colony Count, Microbial
  • Cross Infection / etiology
  • Cross Infection / prevention & control
  • Female
  • Humans
  • Male
  • Povidone-Iodine / therapeutic use
  • Preoperative Care / adverse effects
  • Preoperative Care / methods*
  • Research Design / standards
  • Safety
  • Skin Care / adverse effects
  • Skin Care / methods*
  • Treatment Outcome

Substances

  • Anti-Infective Agents, Local
  • Povidone-Iodine
  • chlorhexidine gluconate
  • 2-Propanol
  • Chlorhexidine