T-cell chronic lymphocytic leukemia: report of a case and review of the literature

Cancer. 1979 Nov;44(5):1652-5. doi: 10.1002/1097-0142(197911)44:5<1652::aid-cncr2820440518>3.0.co;2-d.


We recently observed a unique case of T-cell type chronic lymphocytic leukemia, documented by cell surface marker analyses. Immunologic tests at the time of diagnosis were as follows: 1) skin tests were negative; 2) in vitro lymphocyte responses to antigens or pokeweed mitogen were absent; 3) in vitro lymphocyte responses to phytohemagglutinin, concanavalin-A or allogeneic cells were low but significant; and 4) stimulating capacity of leukemic T cells were absent. Chromosomal analysis of bone marrow showed a pattern of 45 chromosomes with a marker chromosome. Terminal deoxynucleotidyl transferase activity was very low. Patient responded extremely well to COP (cyclophosphamide-oncovin-prednisone) therapy. Patient died of recurrent transitional cell carcinoma while his leukemia was in complete remission, approximately 20 months after the diagnosis of T-cell CLL.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Genetic Markers
  • Humans
  • In Vitro Techniques
  • Leukemia, Lymphoid / genetics
  • Leukemia, Lymphoid / immunology*
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • Male
  • Mitogens / pharmacology
  • Rosette Formation
  • Skin Tests
  • T-Lymphocytes / immunology*


  • Genetic Markers
  • Mitogens