Sequencing of cyclodepsipeptides (destruxins) using positive fast atom bombardment desorption tandem mass spectrometry

Biol Mass Spectrom. 1992 Jan;21(1):33-42. doi: 10.1002/bms.1200210108.

Abstract

The development of fast atom bombardment tandem mass spectrometry methodology is applied to the sequencing of the destruxin toxins (cyclodepsipeptides) which are 'wrong' cyclopeptides. The strategy is discussed in detail. Possible ways to overcome problems related to the resolution of isobaric fragment ions using deuterated compounds and the distinction between sequence and retrosequence are examined.

MeSH terms

  • Amino Acid Sequence
  • Depsipeptides*
  • Fungal Proteins*
  • Molecular Sequence Data
  • Peptides, Cyclic / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment

Substances

  • Depsipeptides
  • Fungal Proteins
  • Peptides, Cyclic
  • destruxin A
  • destruxin E