Immunohistochemical expression of beta-catenin in solitary fibrous tumors

Arch Pathol Lab Med. 2005 Jun;129(6):776-9. doi: 10.1043/1543-2165(2005)129[776:IEOCIS]2.0.CO;2.

Abstract

Context: Immunohistochemical staining for beta-catenin may be used as an indicator of the integrity of the Wnt signaling and beta-catenin degradation pathways. Among mesenchymal tumors, aberrant nuclear localization of beta-catenin is seen in desmoid-type fibromatoses but has not been described for solitary fibrous tumors that may mimic the former lesions, especially in small biopsy samples.

Objective: To study the immunohistochemical expression of beta-catenin in solitary fibrous tumors.

Design: We performed immunohistochemical staining for beta-catenin in 12 solitary fibrous tumors, one of which showed histologic features of malignancy.

Results: All the tumors showed strong and diffuse reactivity for beta-catenin. Four tumors (33%) showed nuclear staining for beta-catenin, whereas the remaining tumors showed either a membranous or mixed membranous and cytoplasmic pattern of staining. The only histologically malignant tumor of the group showed a mixed membranous and cytoplasmic pattern of staining for beta-catenin.

Conclusions: Immunohistochemical staining for beta-catenin in solitary fibrous tumors does not show a consistent pattern, which may be due to differences in tumorigenesis. Larger studies with clinical follow-up are required for estimating the impact of the variable staining pattern on clinical behavior of these tumors.

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism
  • Cell Nucleus / metabolism
  • Cell Nucleus / pathology
  • Cytoplasm / metabolism
  • Cytoplasm / pathology
  • Female
  • Fibroma / metabolism*
  • Fibroma / pathology
  • Humans
  • Immunohistochemistry / methods*
  • Male
  • Middle Aged
  • Soft Tissue Neoplasms / metabolism*
  • Soft Tissue Neoplasms / pathology
  • beta Catenin / metabolism*

Substances

  • Biomarkers, Tumor
  • beta Catenin