A rare case of periosteal osteoblastoma located in the frontal cranial bone

Arch Pathol Lab Med. 2005 Jun;129(6):787-9. doi: 10.5858/2005-129-787-ARCOPO.


Periosteal osteoblastoma is an extremely rare bone-forming neoplasm located on the surface of cortical bone. Of the fewer than 30 cases of periosteal osteoblastomas found in the literature, 2 have been reported to be located in cranial bone, and these have not been documented in detail with clinical history, radiographic findings, macroscopic features, and microscopic findings. Although the differential diagnoses of periosteal lesions include parosteal and periosteal osteosarcoma, periosteal chondroma and chondrosarcoma, osteochondroma, osteoid osteoma, periostitis ossificans, and myositis ossificans, an important differential diagnosis both radiologically and pathologically of such a lesion in the cranium is meningioma. We report an unusual case of periosteal osteoblastoma located in the frontal cranial bone that was radiologically consistent with a meningioma. The differential diagnosis of metaplastic meningioma with differentiation toward bone is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Craniotomy
  • Diagnosis, Differential
  • Dura Mater / pathology
  • Embolization, Therapeutic
  • Female
  • Frontal Bone / pathology*
  • Headache / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Meningeal Neoplasms / diagnosis
  • Meningioma / diagnosis
  • Osteoblastoma / complications
  • Osteoblastoma / pathology*
  • Osteoblastoma / therapy
  • Periosteum / pathology*
  • Skull Neoplasms / complications
  • Skull Neoplasms / pathology*
  • Skull Neoplasms / therapy