Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae

Biochim Biophys Acta. 2005 Jul 10;1744(3):438-54. doi: 10.1016/j.bbamcr.2005.04.004.


The late Golgi compartment is a major protein sorting station in the cell. Secreted proteins, cell surface proteins, and proteins destined for endosomes or lysosomes must be sorted from one another at this compartment and targeted to their correct destinations. The molecular details of protein trafficking pathways from the late Golgi to the endosomal system are becoming increasingly well understood due in part to information obtained by genetic analysis of yeast. It is now clear that proteins identified in yeast have functional homologues (orthologues) in higher organisms. We will review the molecular mechanisms of protein targeting from the late Golgi to endosomes and to the vacuole (the equivalent of the mammalian lysosome) of the budding yeast Saccharomyces cerevisiae.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Endosomes / metabolism
  • Golgi Apparatus / metabolism*
  • Membrane Fusion
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mutation
  • Protein Transport / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Vacuoles / metabolism*


  • Membrane Proteins
  • Saccharomyces cerevisiae Proteins