Redox status of dogs with non-hodgkin lymphomas. An ESR study

Cancer Lett. 2005 Jun 28;224(2):339-46. doi: 10.1016/j.canlet.2004.11.037. Epub 2004 Dec 25.

Abstract

Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / analysis*
  • Cell Proliferation
  • Dog Diseases / physiopathology*
  • Dogs
  • Female
  • Free Radicals / blood*
  • Lymphoma, Non-Hodgkin / physiopathology*
  • Lymphoma, Non-Hodgkin / veterinary*
  • Male
  • Oxidative Stress
  • Spectrum Analysis

Substances

  • Antioxidants
  • Free Radicals