Highly prevalent putative quadruplex sequence motifs in human DNA

Nucleic Acids Res. 2005 May 24;33(9):2901-7. doi: 10.1093/nar/gki553. Print 2005.


We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex containing CCTGT in the first 'loop' position. Being able to highlight types of potential quadruplex sequences in G-rich regions is an important step in searching for biologically relevant sequences and finding their function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Computational Biology
  • DNA / chemistry*
  • G-Quadruplexes
  • Genome, Human*
  • Guanine / analysis*
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Sequence Analysis, DNA


  • Guanine
  • DNA