Retinal remodeling during retinal degeneration

Exp Eye Res. 2005 Aug;81(2):123-37. doi: 10.1016/j.exer.2005.03.006.


Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Mutation
  • Neuronal Plasticity*
  • Photoreceptor Cells, Vertebrate / pathology
  • Rats
  • Rats, Mutant Strains
  • Retinal Degeneration / genetics
  • Retinal Degeneration / pathology*
  • Retinal Degeneration / physiopathology
  • Signal Transduction
  • Visual Pathways / physiopathology