BMP signalling: synergy and feedback create a step gradient

Curr Biol. 2005 May 24;15(10):R375-7. doi: 10.1016/j.cub.2005.05.003.

Abstract

More than a decade ago, genetic evidence predicted the existence of a Dpp gradient in the early Drosophila embryo. Two recent studies finally reveal Dpp distribution, providing further insights into the mechanism of BMP gradient formation.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Body Patterning / physiology*
  • Bone Morphogenetic Proteins / metabolism*
  • Drosophila / embryology*
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism*
  • Embryo, Nonmammalian / metabolism
  • Gene Expression Regulation, Developmental*
  • Models, Biological
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • SCW protein, Drosophila
  • Transforming Growth Factor beta
  • dpp protein, Drosophila