A population based seroepidemiological survey of Chlamydia pneumoniae infections in schoolchildren

J Clin Pathol. 2005 Jun;58(6):617-20. doi: 10.1136/jcp.2004.024380.


Aim: A serosurvey was carried out in schoolchildren from a northeastern area of Italy to define the burden of Chlamydia pneumoniae infection.

Methods: A sample of 649 schoolchildren underwent a simplified version of the International Study of Asthma and Allergies in Childhood questionnaire and IgG and IgA antibodies were investigated using an enzyme immunoassay, followed by a microimmunofluorescence assay in reactive sera.

Results: Of the children examined, 29% and 19.7% had IgG and IgA antibodies, respectively. The IgG prevalence increased with age. No other sociodemographical variable was related to C pneumoniae infection. An association was established between IgA prevalence and previous otitis media.

Conclusions: A mesoendemic (intermediate between high and low endemic level) pattern of C pneumoniae infection is present in schoolchildren from this area and the prevalence rate is related to age. Moreover, this is the first epidemiological evidence of the role of C pneumoniae in otitis.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Antibodies, Bacterial / blood
  • Child
  • Child, Preschool
  • Chlamydophila Infections / epidemiology*
  • Chlamydophila pneumoniae* / immunology
  • Female
  • Fluorescent Antibody Technique / methods
  • Humans
  • Immunoenzyme Techniques / methods
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Italy / epidemiology
  • Male
  • Otitis Media / microbiology
  • Seroepidemiologic Studies
  • Sex Distribution


  • Antibodies, Bacterial
  • Immunoglobulin A
  • Immunoglobulin G