Multicenter study of the mechanisms of resistance and clonal relationships of Streptococcus agalactiae isolates resistant to macrolides, lincosamides, and ketolides in Spain

J J Gonzalez; A Andreu; Spanish Group for the Study of Perinatal Infection from the Spanish Society for Clinical Microbiology and Infectious Diseases

doi:10.1128/AAC.49.6.2525-2527.2005

Multicenter study of the mechanisms of resistance and clonal relationships of Streptococcus agalactiae isolates resistant to macrolides, lincosamides, and ketolides in Spain

Antimicrob Agents Chemother. 2005 Jun;49(6):2525-7. doi: 10.1128/AAC.49.6.2525-2527.2005.

Authors

J J Gonzalez¹, A Andreu; Spanish Group for the Study of Perinatal Infection from the Spanish Society for Clinical Microbiology and Infectious Diseases

Affiliation

¹ Servicio de Microbiología, Hospital Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.

Abstract

Macrolide, lincosamide, and ketolide mechanisms of resistance and clonal relationships were characterized in a collection of 79 resistant group B streptococcus isolates obtained from neonates or pregnant women. The erm(B), erm(TR), and mef(A) genes were present in 62%, 30.4%, and 3.8% of the isolates, respectively. There was considerable clonal diversity among them.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics
Drug Resistance, Multiple, Bacterial / genetics
Erythromycin / pharmacology
Female
Humans
Infant, Newborn
Ketolides / pharmacology*
Lincosamides
Macrolides / pharmacology*
Microbial Sensitivity Tests
Pregnancy
Pregnancy Complications, Infectious / epidemiology
Pregnancy Complications, Infectious / microbiology
Spain / epidemiology
Streptococcal Infections / epidemiology
Streptococcal Infections / microbiology*
Streptococcus agalactiae / drug effects*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Ketolides
Lincosamides
Macrolides
Erythromycin
telithromycin