Synthesis of polymeric thiazolidinediones and L-ascorbic acid towards the development of insulin-sensitizer

Arch Pharm Res. 2005 Apr;28(4):377-81. doi: 10.1007/BF02977664.

Abstract

Polymers, containing 5-(4-O-methylacryloylbenzyl)thiazolidine-2,4-dione [MABTZD]; poly (MABTZD), poly(MABTZD-co-AA) and poly(MABTZD-co-AMAA), were prepared, and identified by FT-IR, 1H- and 13C-NMR spectra. The MABTZD unit contents in poly(MABTZD-co-AA) and poly(MABZD-co-AMAA) were 11.3 and 27.7 mol %, respectively. The number average molecular weights of the polymers, as determined by GPC, ranged from 16,800 to 22,300, and with polydispersity indices of 1.2-1.4.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ascorbic Acid / chemistry*
  • Cell Line
  • Chlorocebus aethiops
  • Drug Stability
  • Hypoglycemic Agents / chemical synthesis*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology
  • Molecular Structure
  • Molecular Weight
  • PPAR gamma / metabolism*
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Polymers / pharmacology
  • Thiazolidinediones / chemical synthesis*
  • Thiazolidinediones / chemistry
  • Thiazolidinediones / pharmacology

Substances

  • Hypoglycemic Agents
  • PPAR gamma
  • Polymers
  • Thiazolidinediones
  • Ascorbic Acid