Presynaptic calcium stores and synaptic transmission

Curr Opin Neurobiol. 2005 Jun;15(3):275-81. doi: 10.1016/j.conb.2005.05.003.


Following the gradual recognition of the importance of intracellular calcium stores for somatodendritic signaling in the mammalian brain, recent reports have also indicated a significant role of presynaptic calcium stores. Ryanodine-sensitive stores generate local, random calcium signals that shape spontaneous transmitter release. They amplify spike-driven calcium signals in presynaptic terminals, and consequently enhance the efficacy of transmitter release. They appear to be recruited by an association with certain types of calcium-permeant ion channels, and they induce specific forms of synaptic plasticity. Recent research also indicates a role of inositoltrisphosphate-sensitive presynaptic calcium stores in synaptic plasticity.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Long-Term Potentiation / physiology
  • Models, Neurological*
  • Neurotransmitter Agents / metabolism
  • Presynaptic Terminals / metabolism*
  • Ryanodine / metabolism
  • Ryanodine Receptor Calcium Release Channel / metabolism
  • Synaptic Transmission / physiology*


  • Neurotransmitter Agents
  • Ryanodine Receptor Calcium Release Channel
  • Ryanodine
  • Calcium