About the mechanism of hiccup

Eur Neurol. 1992;32(3):159-63. doi: 10.1159/000116815.


Every new empiric observation made over two millenia fueled the dispute as to whether hiccup (Hc) is a digestive or a respiratory reflex. A review of the literature, focusing attention on the probable mechanism of Hc, shows Hc as a neurogenic dysfunction of the 'valve function' between the inspiratory complex and the glottis closure complex.

Publication types

  • Review

MeSH terms

  • Glottis / innervation
  • Hiccup / physiopathology*
  • Humans
  • Medulla Oblongata / physiopathology
  • Motor Neurons / physiology
  • Neural Inhibition / physiology
  • Pulmonary Ventilation / physiology