Familial bilateral acinic cell carcinoma of the parotid synchronous with pituitary adenoma: case report

Head Neck. 2005 Sep;27(9):825-8. doi: 10.1002/hed.20219.


Background: Acinic cell carcinoma is a common neoplasm of the salivary glands that occurs predominately in the parotid. Only one case of a familial recurrence of such a neoplasm and 16 cases of bilateral tumors have been reported.

Methods: History files and histologic reports of a patient with bilateral multifocal acinic cell carcinoma of the parotid and a synchronous pituitary adenoma, and of the patient's sister and his father, also treated for parotid tumours, were retrieved.

Results: There was one recurrence of acinic cell carcinoma in the family. A pituitary tumor was a chromophobe gonotrophic adenoma.

Conclusions: This is the 17th case of bilateral acinic cell carcinoma of the parotid gland and the second reported case with a familial recurrence. It is the first with a synchronous pituitary adenoma.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / diagnosis*
  • Carcinoma, Acinar Cell / diagnosis*
  • Carcinoma, Acinar Cell / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary / diagnosis*
  • Parotid Neoplasms / diagnosis*
  • Parotid Neoplasms / genetics
  • Pituitary Neoplasms / diagnosis*