The management of xerostomia in patients on haemodialysis: comparison of artificial saliva and chewing gum

Palliat Med. 2005 Apr;19(3):202-7. doi: 10.1191/0269216305pm1009oa.


Many patients on haemodialysis (HD) therapy suffer from a dry mouth and xerostomia. This can be relieved by mechanical and gustatory stimulation or palliative care. The aim of this crossover study was to investigate the effect and preferences of a sugar-free chewing gum (Freedent White) and a xanthan gum-based artificial saliva (Xialine) in the management of xerostomia in chronic HD patients. Sixty-five HD patients participated in a 6-week crossover trial. The artificial saliva was rated significantly lower than the chewing gum for effectiveness, taste and a global assessment. No preference differences were found for gender and age, although older subjects rated the artificial saliva with a higher mark. Thirty-nine subjects (60%) preferred chewing gum, 15% (n=10) preferred the artificial saliva. Therefore, both chewing gum and artificial saliva could play an important role in the palliative care of xerostomia in HD patients.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Chewing Gum*
  • Cross-Over Studies
  • Humans
  • Middle Aged
  • Patient Compliance
  • Renal Dialysis / adverse effects*
  • Saliva, Artificial / therapeutic use*
  • Xerostomia / etiology
  • Xerostomia / therapy*


  • Chewing Gum
  • Saliva, Artificial