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, 68 (5), 734-8

Cytotoxic Arylnaphthalene Lignans From a Vietnamese Acanthaceae, Justicia Patentiflora

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Cytotoxic Arylnaphthalene Lignans From a Vietnamese Acanthaceae, Justicia Patentiflora

Sophie Susplugas et al. J Nat Prod.

Abstract

One new norlignan (1) and five new lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines and arrest the cell cycle in the G0/G1 phase.

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