Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora

J Nat Prod. 2005 May;68(5):734-8. doi: 10.1021/np050028u.


One new norlignan (1) and five new lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines and arrest the cell cycle in the G0/G1 phase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acanthaceae / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Cycle / drug effects
  • Drug Screening Assays, Antitumor
  • G1 Phase / drug effects
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Resting Phase, Cell Cycle / drug effects
  • Tumor Cells, Cultured
  • Vietnam


  • Antineoplastic Agents, Phytogenic
  • Lignans
  • justicinol
  • justiflorinol
  • patentiflorin A