Abstract
An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2''',3'''-epoxy-3'''-methyl-butyl]-2-[2''-methyl-butanoyl]-4-[3'-methyl-2''-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 microg/ml.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology
-
Epoxy Compounds / isolation & purification*
-
Epoxy Compounds / pharmacology
-
Hypericum / chemistry*
-
Inhibitory Concentration 50
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Phloroglucinol / analogs & derivatives*
-
Phloroglucinol / isolation & purification
-
Phloroglucinol / pharmacology
-
Plant Components, Aerial / chemistry
-
Plant Extracts / isolation & purification
-
Staphylococcus aureus / drug effects*
Substances
-
1,3,5-trihydroxy-6-(2''',3'''-epoxy-3'''-methyl-butyl)-2-(2''-methyl-butanoyl)-4-(3'-methyl-2''-butenyl)-benzene
-
Anti-Bacterial Agents
-
Epoxy Compounds
-
Plant Extracts
-
Phloroglucinol