Notch to remember

Trends Neurosci. 2005 Aug;28(8):429-35. doi: 10.1016/j.tins.2005.05.003.


Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain. Here, we review evidence from recent studies indicating that Notch signaling is required for formation of long-term memories, and discuss possible memory processes modulated by this pathway. We also consider the possible involvement of Notch signaling in cognitive disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Cognition Disorders / genetics
  • Cognition Disorders / metabolism
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Memory / physiology*
  • Models, Neurological
  • Neuronal Plasticity / physiology
  • Receptors, Notch
  • Signal Transduction / physiology*


  • Membrane Proteins
  • Receptors, Notch