Haplotype-based genetics in mice and rats

Trends Genet. 2005 Jun;21(6):318-22. doi: 10.1016/j.tig.2005.03.010.


Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Animals
  • Chromosomes, Mammalian / genetics*
  • Genotype
  • Haplotypes*
  • Mice / genetics*
  • Polymorphism, Single Nucleotide
  • Rats / genetics*